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CHAPTER XI Regional Arrangements Article 44 (a) The Health Assembly shall from time to time define the geographical areas in which it is desirable to establish a regional organization. (b) The Health Assembly may, with the consent of a majority of the Members situated within each area so defined, establish a regional organization to meet the special needs of such area. There shall not be more than one regional organization in each area. Article 45 Each regional organization shall be an integral part of the Organization in accordance with this Constitution. Article 46 Each regional organization shall consist of a Regional Committee and a Regional Office. Article 47 Regional Committees shall be composed of representatives of the Member States and Associate Members in the region concerned. Territories or groups of territories within the region, which are not responsible for the conduct of their international relations and which are not Associate Members, shall have the right to be represented and to participate in Regional Committees. The nature and extent of the rights and obligations of these territories or groups of territories in Regional Committees shall be determined by the Health Assembly in consultation with the Member or other authority having responsibility for the international relations of these territories and with the Member States in the region. Article 48 Regional Committees shall meet as often as necessary and shall determine the place of each meeting. Article 49 Regional Committees shall adopt their own rules of procedure. Article 50 The functions of the Regional Committee shall be : (a) To formulate policies governing matters of an exclusively regional character; (b) To supervise the activities of the Regional Office ;